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Monday, August 3, 2020 | History

4 edition of Mechanisms of DNA damage recognition in mammalian cells found in the catalog.

Mechanisms of DNA damage recognition in mammalian cells

by Hanspeter Naegeli

  • 139 Want to read
  • 6 Currently reading

Published by Chapman & Hall, Landes Bioscience in New York, Austin, Tex., U.S.A .
Written in English

    Subjects:
  • DNA repair.,
  • DNA damage.,
  • Mammals -- Molecular genetics.,
  • DNA Damage -- physiology.,
  • Mammals -- genetics.,
  • Cells, Cultured.,
  • Transcription, Genetic.,
  • DNA Repair.

  • Edition Notes

    Includes bibliographical references and index.

    StatementHanspeter Naegeli.
    SeriesMolecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)
    Classifications
    LC ClassificationsQH467 .N34 1997
    The Physical Object
    Pagination210 p. :
    Number of Pages210
    ID Numbers
    Open LibraryOL661024M
    ISBN 100412133113, 1570594384
    LC Control Number97006442

    MOLECULAR MECHANISMS OF MAMMALIAN DNA REPAIR AND THE DNA DAMAGE CHECKPOINTS Aziz Sancar,1 Laura A. Lindsey-Boltz,1 Keziban U¨ nsal-Kac¸maz,1 and Stuart Linn2 1Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina ; email: [email protected], [email protected], . DNA damage is one of the most common insults that challenge all cells. To cope, an elaborate molecular and cellular response has evolved to sense, respond to and correct the damage. This allows the maintenance of DNA fidelity essential for normal cell viability and the prevention of genomic instability that can lead to tumor formation. In the context of oocytes, the impact of DNA damage is not Cited by:

      A) Direct Damage Reversal The direct reversal of DNA damage is by far the simplest repair mechanism that involves a single polypeptide chain, with enzymatic properties which binds to the damage and restores the DNA genome to its normal state in a single-reaction step. Mechanisms of the dna repair in bacterial and yeast cells Base excision repair Base excision repair constitutes the primary defense against lesions that do not heavily distort the DNA struc-ture. BER is responsible for the removal of a variety of lesions. These include spontaneous hydrolytic depuri-nation of DNA, deamination of bases, products.

      Stands as the most comprehensive guide to the subject-covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employeCited by: In a mammalian cell, DNA repair systems: A) are extraordinarily efficient energetically. B) are generally absent, except in egg and sperm cells. C) can repair deletions, but not mismatches. D) can repair most types of lesions except those caused by UV light. E) normally .


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Mechanisms of DNA damage recognition in mammalian cells by Hanspeter Naegeli Download PDF EPUB FB2

Mechanisms of DNA Damage Recognition in Mammalian Cells. Authors (view affiliations) Molecular Determinants of Damage Recognition by Mammalian Nucleotide Excision Repair.

Hanspeter Naegeli. Pages Recognition of DNA Damage During Replication. Hanspeter Naegeli. Pages DNA Damage Recognition: Toxicological and Medical. Mechanisms of DNA Damage Recognition in Mammalian Cells Mechanisms of DNA Damage Recognition in Mammalian Cells.

Authors: Naegeli, Hanspeter Buy this book eB40 € price for Spain (gross) Buy eBook ISBN Brand: Springer US. Get this from a library. Mechanisms of DNA damage recognition in mammalian cells. [Hanspeter Naegeli]. Mechanisms of DNA Damage Recognition in Mammalian Cells (Molecular Biology Intelligence Unit) th Edition by Hanspeter Naegeli (Author) › Visit Amazon's Hanspeter Naegeli Page.

Find all the books, read about the author, and more. See search results for this author. Are you an author. Cited by: 1. DNA Repair (Amst). Aug; doi: / Epub May Molecular mechanisms of DNA damage recognition for mammalian Cited by: Mechanisms of DNA damage recognition in mammalian cells.

[Hanspeter Naegeli] Mechanisms of DNA damage recognition in mammalian cells. New York: Chapman & Hall ; Austin, Tex., U.S.A.: Landes Bioscience, © Recognition of DNA Damage During Replication.- DNA Damage Recognition: Toxicological and Medical Prospects.

Series. DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular responses that enable the cell either to eliminate or cope with the damage or to activate a programmed cell death process, presumably to eliminate cells with potentially Cited by: Abstract.

If left uncorrected, DNA damage poses multiple threats to the proper functioning of DNA. First, many DNA lesions cause cytotoxic cell death by interfering with essential transactions such as transcription or DNA replication.

1,2 Second, DNA lesions induce lethality by triggering pathways of programmed cell death (apoptosis). 3,4 Third, cells that survive are subject to permanent Author: Hanspeter Naegeli. Excision repair is a major set of pathways by which damage is removed from DNA; mutations that affect excision result in large increases (5–10 fold) in UV sensitivity in mammalian cells.

Mutations that affect excision-repair indirectly, or that affect the cell cycle, DNA chain growth, replicon organization, etc., may result in smaller.

In mammalian cells, this sophisticated system consists of at least four xeroderma pigmentosum (XP)-related factors: XPC, UV-DDB, TFIIH, and XPA. Here, I discuss recent advances in our understanding of the detailed molecular mechanisms underlying DNA damage recognition for global genomic NER.

XPC as a versatile damage sensor Cited by:   This book summarizes existing knowledge on how these DNA damage processing pathways are selectively targeted to defective sites in the mammalian genome.

It discusses the biological, clinical and toxicological implications of DNA damage recognition in a comprehensive : Hanspeter Naegeli.

DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester bonds. We aim to elucidate the structures and catalytic mechanisms of DNA ligases from diverse taxa, especially the basis for nick sensing.

DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular responses that enable the. Cells encounter DNA damage induced by both endogenous and exogenous factors, and have evolved damage-specific repair pathways.

DNA is an important of target radiation. For mammalian nucleotide excision repair (NER), DNA lesions are recognized in at least two steps involving detection of unpaired bases by the XPC protein complex and the subsequent verification of injured bases.

Although lesion verification is important to ensure high damage discrimination and the accuracy of the repair system, it has been unclear how this is by:   Because mammalian MMR proteins interact with a broad spectrum of DNA lesions 6, this model is consistent with the notion that MutSα/MutLα acts as Cited by: DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death.

Damage to DNA induces several cellular responses that enable the cell either to eliminate or cope with the damage or to activate a programmed cell death process, presumably to eliminate cells with potentially catastrophic mutations.

These DNA damage response Cited by:   Replicative Bypass Mechanisms in Mammalian Cells: Workshop Summary DNA Replication in Ultraviolet-Irradiated Mammalian Cells Pyrmidine Dimers in DNA Strands of Mammalian Cells Synthesized after UV-Irradiation On the Presence of UV-Endonuclease Sensitive Sites in Daughter DNA of UV-Irradiated Mammalian Cells Brand: Elsevier Science.

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.

Many of these lesions cause structural damage to the DNA molecule. Replicative Bypass Mechanisms in Mammalian Cells: Workshop Summary DNA Replication in Ultraviolet-Irradiated Mammalian Cells Pyrmidine Dimers in DNA Strands of Mammalian Cells Synthesized after UV-Irradiation On the Presence of UV-Endonuclease Sensitive Sites in Daughter DNA of UV-Irradiated Mammalian Cells Book Edition: 1.

In mammalian cells, direct repair is utilized to repair specific types of DNA and RNA damage caused by ubiquitous alkylating agents. Only two major types of proteins conduct direct repair in mammalian cells, O6-methylguanine-DNA methyltransferase (MGMT or AGT) and ALKBH family Fe(II)/α-ketoglutarate dioxygenases (FeKGDs).Cited by: 1.This book is based on the papers presented at the conference on "Mecha­ nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; Brand: Springer US.Molecular carcinogenesis, mechanisms of DNA repair and mutagenesis in mammalian cells James E.

Haber, Rosenstiel Basic Medical Sciences Research Center, Waltham, Massachusetts, United States Homologous recombination, nonhomologous end-joining and .